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KMID : 0355620100360050386
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Journal of Korean Association of Oral and Maxillofacial Surgeons
2010 Volume.36 No. 5 p.386 ~ p.391
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Expression of osteoclastogenesis related factors in dental implant patients
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Ryu Seong-Hee
Kim Bang-Sin
Jung Seung-Gon
Han Man-Seung
Kook Min-Suk
Ohk Seung-Ho
Oh Hee-Kyun
Park Hong-Ju
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Abstract
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Introduction: Bone resorption is a unique function of osteoclasts. Osteoclasts are a specialized macrophage polykaryon whose differentiation is regulated principally by macrophage colony-stimulating factors, receptor activator of nuclear factor κB ligand (RANK) ligand, osteoprotegerin (OPG), and interleukins (IL). Reflecting the integrin-mediated signals, osteoclasts develop a specialized cytoskeleton that allows it to establish an isolated micro-environment between itself and the bone, wherein matrix degradation occurs by a process involving proton transport. The levels of IL-1, IL-6, OPG, and prostaglandin E2 (PGE2) expression were evaluated to study the correlations between dental implant teeth and the adjacent teeth.
Materials and Methods: The exudate of the gingival crevice acquired from dental implants, adjacent teeth, opposite teeth and contralateral teeth of 24 patients.
Results:
1. The levels of IL-1, IL-6, OPG and PGE2 expression in dental implant teeth were higher than those of the contralateral teeth.
2. IL-1 revealed a higher expression level in the adjacent teeth than in dental implant teeth.
3. The dental implant teeth and adjacent teeth did not show a remarkable difference in the level of IL-1 expression.
4. All the other cytokines were strongly expressed in the dental implant compared to the adjacent teeth.
Conclusion: These results suggest that there might be close correlation between dental implant teeth and adjacent teeth in terms of the expressions of cytokines that affect the development and regulation of osteoclasts.
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KEYWORD
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Dental implants, Cytokines, Osteoclasts
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